THE TIER LIST.

Every peptide ranked by goal. S-tier through F-tier. Opinionated on purpose. Defended with criteria (evidence quality, effect size, safety, accessibility). Click any compound for the full profile with citations.

Ranked by trial-proven weight loss, tolerability, lean-mass preservation, and accessibility.

GOD TIER

Retatrutide

Triple G · LY3437943

28.7% weight loss in Phase 3. Highest number ever recorded. Not yet approved but coming.

Tirzepatide

Mounjaro · Zepbound

FDA-approved, 22.5% weight loss, dual agonist. The current gold standard.

EXCELLENT

Semaglutide

Ozempic · Wegovy

FDA-approved, 15–20% weight loss, years of safety data. The workhorse.

Cagrilintide

AM833 · CagriSema (with semaglutide)

Amylin + sema combo = 22.7% weight loss with better tolerability. Novo's answer to retatrutide.

MID

AOD-9604

HGH Fragment 176-191 · Lipolytic Fragment

HGH fragment. Modest fat loss (~1.3kg vs placebo in Ph III). Clean but not dramatic.

5-Amino-1MQ

5-amino-1-methylquinolinium · NNMT inhibitor

NNMT inhibitor. Strong animal data for lean-mass-preserving fat loss. Early human.

MEH

SLU-PP-332

Exercise Mimetic · ERR Agonist

Exercise mimetic. 50% endurance boost in mice. Zero human data.

◆ TIER CRITERIA

S · GOD TIER

The best-in-class. If you're doing this category, start here.

A · EXCELLENT

Strong evidence, widely effective, well-tolerated.

B · SOLID

Works. Specific use cases or context-dependent.

C · MID

Real research, but middling effect or better alternatives exist.

D · MEH

Thin evidence. Consider skipping unless you have a specific reason.

F · PASS

Not worth it at current evidence level. Niche or superseded.

⚠ HOW TO READ THIS

Rankings reflect current evidence quality (preclinical vs clinical, effect size, replication) and practical utility(tolerability, accessibility, regulatory status). Tiers are not absolute — a B-tier peptide for the wrong goal beats an S-tier peptide used wrong. Click through to full profiles for the nuance we can't fit on this page.

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