PEPGAINS/COMPARE
◆ SIDE-BY-SIDE
COMPARE ANY TWO.
Pick two peptides. See mechanism, dosing, half-life, citations, and risks side-by-side. Useful for choosing between similar compounds (sema vs tirz, BPC vs TB) or exploring new ones.
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RIGHT
| Property | Semaglutide | Tirzepatide |
|---|---|---|
| Status | FDA Approved | FDA Approved |
| Category | weight-loss | weight-loss |
| Half-life | ~7 days | ~5 days |
| Typical dose | Start 0.25mg weekly, titrate to 2.4mg over 16-20 weeks | Start 2.5mg weekly, titrate to 15mg over several months |
| Frequency | Once weekly (injection) or daily (oral) | Once weekly |
| Delivery | subcutaneous · oral | subcutaneous |
| Citations | 5 | 5 |
| Popularity | 100/100 | 95/100 |
| Mechanism | Mimics GLP-1, a hormone that tells your brain you're full, slows digestion, and regulates blood sugar. | Activates TWO hunger receptors (GLP-1 and GIP) for a more powerful appetite-suppressing effect. |
| Top benefit | 15-20% body weight loss in clinical trials | 20-25% body weight loss (best in class) |
| Key risk | Pancreatitis | Nausea |