PPEPGAINS
⚠ RESEARCH USE ONLY · NOT FDA-APPROVED FOR HUMAN USE · NOT MEDICAL ADVICE
PEPGAINS/LIBRARY/LONGEVITY/PINEALON
LONGEVITYAPPROVED (RUSSIA)

Pinealon.

A Russian cognitive/longevity tripeptide — tiny and underrated
AKA · Glu-Asp-Arg · EDR tripeptide
LONGEVITYCOGNITIVESUBCUTANEOUSNASAL

A three-residue peptide (Glu-Asp-Arg) from Khavinson's pineal peptide lineage. Russian clinical research suggests anti-aging and cognitive effects; Western data is near-zero. Short enough to be orally active.

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Minutes plasma; extended cellular
Half-life
3
Citations
2
Routes
2
Categories
58
Popularity

AT A GLANCE.

§ 01 · TL;DR

THE QUICK READ.

A three-residue peptide (Glu-Asp-Arg) from Khavinson's pineal peptide lineage. Russian clinical research suggests anti-aging and cognitive effects; Western data is near-zero. Short enough to be orally active.

A tiny peptide that penetrates cells and appears to modulate gene expression in neurons, supporting repair and cognitive function.

Russian clinical protocols cycle 10-day on / 30-day off.

WHAT IT MIGHT HELP WITH.

1
Cognitive function in age-related decline
2
Neuroprotection in stroke/ischemia models
3
Improves sleep quality (reported)
4
Longevity claims (extensive Khavinson group data)
5
Oral and intranasal routes available

HOW IT WORKS.

§ 02 · MECHANISM

A tiny peptide that penetrates cells and appears to modulate gene expression in neurons, supporting repair and cognitive function.

Penetrates the blood-brain barrier and nuclear membrane. Influences transcription of neuroprotective genes, reduces neuronal apoptosis in oxidative stress models, modulates melatonin/serotonin pathways via the pineal gland.

WHO IT'S FOR
  • ✓Cognitive aging research
  • ✓Sleep/circadian studies
WHO SHOULD AVOID
  • ✕Pregnancy
  • ✕Those on antidepressants without consultation

THE RESEARCH.

§ 03 · 3 STUDIES
2011 · FINDING

Khavinson et al. — epigenetic regulation

Short peptides like Pinealon modulate gene expression via direct DNA binding in chromatin-accessible regions.

2015 · FINDING

Ashapkin et al. — neuroprotection

Pinealon reduced neuronal apoptosis in rat hypoxia model by ~40%.

2014 · FINDING

Khavinson — longevity review

Comprehensive review of pineal peptide research, 30-year Russian cohort data.

DOSING PROTOCOL.

§ 04 · DOSING
TYPICAL RANGE
Russian clinical protocols cycle 10-day on / 30-day off.
10mg subcutaneous daily or nasal spray
FREQUENCY
Most-cited schedule
Once daily for 10–20 day cycles
ROUTES
Delivery methods
SUBCUTANEOUS · NASAL
HALF-LIFE
Steady state drives frequency
Minutes plasma; extended cellular
⚠ NOTE

These are reported protocols from research literature and practitioner accounts, not prescriptions. No FDA-approved human dose exists for research compounds. Anyone using Pinealon should work with a qualified physician and source from a supplier providing third-party COAs.

FORMS AVAILABLE
  • · Lyophilized vial
  • · Nasal spray
⚠ RESEARCH INFORMATION ONLY · NOT MEDICAL ADVICE
Open dosing calculator →

SIDE EFFECTS & RISKS.

§ 06 · SAFETY
·
Minimal reported side effects
Rare · mild
·
Vivid dreams (nasal dosing)
Occasional · mild

WHERE TO SOURCE

§ 07 · SUPPLIER
PEAK LAB
PEPTIDES
SUPPLIER OF RECORD · 12 BATCHES PASSED

We tried nine suppliers across 2025 and kept picking PEAK LAB for Pinealon: 99.4% HPLC purity, COA on every batch, cold chain intact. Shop through our link and we earn a small commission — affiliate relationship is disclosed.

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