PPEPGAINS
⚠ RESEARCH USE ONLY · NOT FDA-APPROVED FOR HUMAN USE · NOT MEDICAL ADVICE
PEPGAINS/LIBRARY/TRENDING/GLUTATHIONE
TRENDINGRESEARCH/SUPPLEMENT

Glutathione.

The Master Antioxidant
AKA · GSH · L-Glutathione · Gamma-Glutamylcysteinylglycine
TRENDINGIMMUNESKIN & ANTI-AGINGORALINTRAVENOUS

The body's most important antioxidant - a tripeptide found in every cell. Research supports its role in detoxification, immune function, and skin health. Popular for skin brightening and anti-aging.

Jump to dosing ↓Read researchBuy at PEAK LAB ↗
~10 minutes in plasma (rapidly taken up by cells); effects depend on cellular stores
Half-life
5
Citations
4
Routes
3
Categories
Store
Storage
80
Popularity

AT A GLANCE.

§ 01 · TL;DR

THE QUICK READ.

The body's most important antioxidant - a tripeptide found in every cell. Research supports its role in detoxification, immune function, and skin health. Popular for skin brightening and anti-aging.

Neutralizes free radicals, supports detoxification in the liver, boosts immune function, and inhibits melanin production for skin brightening.

WHAT IT MIGHT HELP WITH.

1
Powerful antioxidant protection
2
Supports liver detoxification
3
Immune system support
4
Skin brightening and evening tone
5
May reduce oxidative stress markers
6
Supports cellular health

HOW IT WORKS.

§ 02 · MECHANISM

Neutralizes free radicals, supports detoxification in the liver, boosts immune function, and inhibits melanin production for skin brightening.

Tripeptide (glutamate, cysteine, glycine) that serves as the primary intracellular antioxidant. Acts as a cofactor for glutathione peroxidase, neutralizing reactive oxygen species. Conjugates toxins for elimination via glutathione-S-transferases. Inhibits tyrosinase enzyme, reducing melanin synthesis.

WHO IT'S FOR
  • ✓Those seeking antioxidant support
  • ✓Skin brightening and anti-aging
  • ✓Detoxification protocols
  • ✓Immune support
  • ✓Those with high oxidative stress
WHO SHOULD AVOID
  • ✕Those with sulfur sensitivity
  • ✕Asthmatics (IV - may trigger bronchospasm in sensitive individuals)
  • ✕Pregnant or nursing (high-dose IV)

THE RESEARCH.

§ 03 · 5 STUDIES
2003 · FINDING
CITED

Antioxidant Defense

Established as the primary intracellular antioxidant system in humans

Source ↗
2017 · FINDING
CITED

Skin Lightening

Studies showed reduced melanin index and improved skin tone with glutathione supplementation

Source ↗
2015 · FINDING
CITED

Liver Support

Research indicated improved liver function markers in patients with fatty liver disease

Source ↗
2019 · FINDING
CITED

Immune Function

Studies documented enhanced immune cell function with optimal glutathione levels

Source ↗
2024 · FINDING
CITED

Liposomal Bioavailability Study

Liposomal glutathione demonstrated significantly improved oral bioavailability compared to standard forms

Source ↗

DOSING PROTOCOL.

§ 04 · DOSING
TYPICAL RANGE
Research reported dose
Oral: 250-1000mg daily (liposomal preferred). IV: 600-2000mg per session. Injection: 200-600mg
FREQUENCY
Most-cited schedule
Oral daily; IV/injections weekly to monthly
ROUTES
Delivery methods
ORAL · INTRAVENOUS · INTRAMUSCULAR · SUBCUTANEOUS
HALF-LIFE
Steady state drives frequency
~10 minutes in plasma (rapidly taken up by cells); effects depend on cellular stores
STORAGE
Protect from light, refrigerate
Store oral supplements
⚠ NOTE

These are reported protocols from research literature and practitioner accounts, not prescriptions. No FDA-approved human dose exists for research compounds. Anyone using Glutathione should work with a qualified physician and source from a supplier providing third-party COAs.

FORMS AVAILABLE
  • · Oral capsules/liquid (liposomal)
  • · IV infusion
  • · Intramuscular injection
  • · Subcutaneous injection
⚠ RESEARCH INFORMATION ONLY · NOT MEDICAL ADVICE
Open dosing calculator →

COMMON STACKS.

§ 05 · COMBINATIONS
★ SYNERGY
Glutathione + GHK-Cu

The Skin Rejuvenation Peptide

Open GHK-Cu →

SIDE EFFECTS & RISKS.

§ 06 · SAFETY
·
Bloating/cramping
Occasional (oral) · mild
•
Allergic reactions
Rare · moderate
·
Zinc depletion
Possible with long-term use · mild

Consider zinc supplementation

·
Injection site reactions
Occasional · mild

WHERE TO SOURCE

§ 07 · SUPPLIER
PEAK LAB
PEPTIDES
SUPPLIER OF RECORD · 12 BATCHES PASSED

We tried nine suppliers across 2025 and kept picking PEAK LAB for Glutathione: 99.4% HPLC purity, COA on every batch, cold chain intact. Shop through our link and we earn a small commission — affiliate relationship is disclosed.

Visit PEAK LAB ↗

COMMON QUESTIONS.

§ 08 · FAQ
Why is oral glutathione absorption controversial?
Traditional glutathione breaks down in the digestive tract. Research on newer liposomal and sublingual forms shows improved absorption, but IV/injection still provides the most reliable bioavailability.
How does glutathione lighten skin?
Glutathione inhibits tyrosinase, the enzyme that produces melanin. It also converts eumelanin (dark) to pheomelanin (lighter). Results require consistent use over months.
What depletes glutathione levels?
Aging, poor diet, alcohol, acetaminophen, pollution, stress, and chronic illness all reduce glutathione. Modern life creates high demand for this antioxidant.
What's the difference between reduced and oxidized glutathione?
Reduced glutathione (GSH) is the active antioxidant form. When it neutralizes free radicals, it becomes oxidized (GSSG). The body recycles GSSG back to GSH, but this system can become overwhelmed.
Can I take it with NAC instead?
N-acetyl cysteine (NAC) is a precursor that helps the body make its own glutathione. Some prefer NAC for long-term support, while direct glutathione provides immediate antioxidant benefits. Both approaches are valid.
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